Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 13/20 | 0.46 |
| ▸ | INSR | P06213 | 10/20 | 0.46 |
| ▸ | IGF1R | P08069 | 10/20 | 0.46 |
| ▸ | PLK1 | P53350 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | CD74 | P04233 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29791404 | 1.00 | EGFR (0.47) | EGFRALKINSRIGF1RPLK1 | |
| SCHEMBL24620286 | 0.95 | PLK1 (0.48) | EGFRALKINSRIGF1RPLK1 | |
| SCHEMBL24620287 | 0.94 | ALK (0.47) | EGFRALKINSRIGF1RPLK1 | |
| SCHEMBL24620243 | 0.91 | ALK (0.56) | EGFRALKINSRIGF1RPLK1 | |
| SCHEMBL29791462 | 0.91 | ALK (0.56) | EGFRALKINSRIGF1RPLK1 | |
| SCHEMBL24620285 | 0.91 | ALK (0.46) | EGFRALKINSRIGF1RLRRK2 | |
| SCHEMBL24620341 | 0.88 | ALK (0.42) | EGFRALKLRRK2PTK2 | |
| SCHEMBL24620340 | 0.83 | ALK (0.44) | EGFRALKFLT3PTK2BTK | |
| SCHEMBL30833026 | 0.83 | ALK (0.44) | EGFRALKFLT3PTK2BTK | |
| SCHEMBL24620633 | 0.82 | ALK (0.56) | EGFRALKINSRIGF1RPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147622-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |