Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 7/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 4/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833026 | 1.00 | ALK (0.44) | ALKPTK2BRD4EGFRULK1 | |
| SCHEMBL24620285 | 0.87 | ALK (0.46) | ALKPTK2EGFRMAP4K1 | |
| SCHEMBL29791404 | 0.83 | EGFR (0.47) | ALKPTK2EGFRFLT3BTK | |
| SCHEMBL24620222 | 0.83 | EGFR (0.47) | ALKPTK2EGFRFLT3BTK | |
| SCHEMBL29791465 | 0.82 | CCNK (0.48) | ALKEGFRCCND3CCNA2CDK2 | |
| SCHEMBL24620378 | 0.82 | CCNK (0.48) | ALKEGFRCCND3CCNA2CDK2 | |
| SCHEMBL29791545 | 0.82 | ALK (0.52) | ALKPTK2EGFRMAP4K1 | |
| SCHEMBL24620270 | 0.82 | ALK (0.52) | ALKPTK2EGFRMAP4K1 | |
| SCHEMBL24620155 | 0.81 | EGFR (0.51) | ALKPTK2EGFRCCND3CCNA2 | |
| SCHEMBL30833021 | 0.81 | EGFR (0.51) | ALKPTK2EGFRCCND3CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147622-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |