Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 10/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.39 |
| ▸ | AXL | P30530 | 3/20 | 0.39 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.39 |
| ▸ | WEE1 | P30291 | 2/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24620229 | 0.81 | MAP4K1 (0.69) | MAP4K1ALKMET | |
| SCHEMBL30833042 | 0.81 | MAP4K1 (0.69) | MAP4K1ALKMET | |
| SCHEMBL24620227 | 0.78 | MAP4K1 (0.54) | MAP4K1ALK | |
| SCHEMBL24620240 | 0.75 | MAP4K1 (0.54) | MAP4K1 | |
| SCHEMBL24620202 | 0.72 | MAP4K1 (0.41) | MAP4K1ALKAXLMET | |
| SCHEMBL20214385 | 0.70 | MAP4K1 (1.00) | MAP4K1ALK | |
| SCHEMBL29791374 | 0.69 | AXL (0.63) | MAP4K1ALKAXLWEE1MET | |
| SCHEMBL24620281 | 0.69 | AXL (0.63) | MAP4K1ALKAXLWEE1MET | |
| SCHEMBL18760005 | 0.69 | ALK (0.76) | MAP4K1ALK | |
| SCHEMBL24620351 | 0.69 | MAP4K1 (0.51) | MAP4K1ALKWEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147622-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |