Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.51 |
| ▸ | ULK1 | O75385 | 3/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24620455 | 0.90 | MAP4K1 (0.51) | MAP4K1ULK1ALKBTK | |
| SCHEMBL24620240 | 0.87 | MAP4K1 (0.54) | MAP4K1 | |
| SCHEMBL24620202 | 0.85 | MAP4K1 (0.41) | MAP4K1ALKBTKEGFR | |
| SCHEMBL24620193 | 0.81 | MAP4K1 (0.56) | MAP4K1ULK1ALK | |
| SCHEMBL24620173 | 0.81 | ALK (0.52) | MAP4K1ALKBTKEGFR | |
| SCHEMBL24620306 | 0.81 | ALK (0.52) | MAP4K1ALKBTKEGFR | |
| SCHEMBL24620485 | 0.79 | BTK (0.47) | MAP4K1ALKBTK | |
| SCHEMBL26778400 | 0.78 | MAP4K1 (0.52) | MAP4K1ALKPTK2BTKWEE1 | |
| SCHEMBL24620221 | 0.77 | MAP4K1 (0.53) | MAP4K1ALKBTKEGFR | |
| SCHEMBL24620264 | 0.77 | MAP4K1 (0.56) | MAP4K1ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147622-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |