Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 17/20 | 0.59 |
| ▸ | ROS1 | P08922 | 4/20 | 0.59 |
| ▸ | INSR | P06213 | 13/20 | 0.57 |
| ▸ | IGF1R | P08069 | 13/20 | 0.57 |
| ▸ | EGFR | P00533 | 5/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 2/20 | 0.54 |
| ▸ | NUAK1 | O60285 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | STK10 | O94804 | 2/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | FYN | P06241 | 2/20 | 0.54 |
| ▸ | FES | P07332 | 2/20 | 0.54 |
| ▸ | CSF1R | P07333 | 2/20 | 0.54 |
| ▸ | YES1 | P07947 | 2/20 | 0.54 |
| ▸ | LYN | P07948 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29791434 | 1.00 | ALK (0.59) | ALKROS1INSRIGF1REGFR | |
| SCHEMBL29791425 | 0.93 | ALK (0.67) | ALKROS1INSRIGF1REGFR | |
| SCHEMBL24620376 | 0.93 | ALK (0.67) | ALKROS1INSRIGF1REGFR | |
| SCHEMBL24620261 | 0.89 | ALK (0.52) | ALKROS1INSRIGF1REGFR | |
| SCHEMBL24620243 | 0.86 | ALK (0.56) | ALKROS1INSRIGF1REGFR | |
| SCHEMBL29791462 | 0.86 | ALK (0.56) | ALKROS1INSRIGF1REGFR | |
| SCHEMBL22462106 | 0.83 | INSR (0.77) | ALKROS1INSRIGF1REGFR | |
| SCHEMBL24620619 | 0.82 | ALK (0.64) | ALKROS1INSRIGF1REGFR | |
| SCHEMBL29791360 | 0.82 | ALK (0.64) | ALKROS1INSRIGF1REGFR | |
| SCHEMBL24620270 | 0.82 | ALK (0.52) | ALKROS1EGFRPTK2MAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147622-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |