Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 17/20 | 0.57 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24620377 | 1.00 | ALK (0.57) | ALKMAP4K1INSR | |
| SCHEMBL30833048 | 0.90 | MAP4K1 (0.68) | ALKMAP4K1 | |
| SCHEMBL30833017 | 0.90 | MAP4K1 (0.68) | ALKMAP4K1 | |
| SCHEMBL24620201 | 0.90 | MAP4K1 (0.68) | ALKMAP4K1 | |
| SCHEMBL24620274 | 0.90 | MAP4K1 (0.68) | ALKMAP4K1 | |
| SCHEMBL29119575 | 0.87 | ALK (0.57) | ALKMAP4K1INSR | |
| SCHEMBL24620253 | 0.86 | ALK (0.64) | ALKMAP4K1INSR | |
| SCHEMBL29791331 | 0.86 | ALK (0.64) | ALKMAP4K1INSR | |
| SCHEMBL24620289 | 0.85 | ALK (0.67) | ALKMAP4K1INSR | |
| SCHEMBL24620328 | 0.85 | ALK (0.67) | ALKMAP4K1INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240092763-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | SINAI HEALTH SYSTEM (CA) | 2024-03-21 | — | — | US | claimed |
| US-20240092763-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | SINAI HEALTH SYSTEM (CA) | 2024-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240092763-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | NUAK1, NUAK2, NEK1 | ALK 430/4885MAP4K1 55/4885INSR 1031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.