Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 12/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24620361 | 0.85 | MAP4K1 (0.53) | MAP4K1 | |
| SCHEMBL24620447 | 0.79 | BTK (0.40) | MAP4K1BTKALK | |
| SCHEMBL24620276 | 0.73 | BTK (0.45) | MAP4K1BTKALK | |
| SCHEMBL24620219 | 0.70 | JAK3 (0.34) | BTKALK | |
| SCHEMBL24620259 | 0.69 | JAK3 (0.35) | BTKALK | |
| SCHEMBL24620202 | 0.66 | MAP4K1 (0.41) | MAP4K1BTKALK | |
| SCHEMBL26970255 | 0.64 | MAP4K1 (0.81) | MAP4K1 | |
| SCHEMBL30689952 | 0.64 | MAP4K1 (0.81) | MAP4K1 | |
| SCHEMBL24040086 | 0.63 | MAP4K1 (1.00) | MAP4K1ALK | |
| SCHEMBL20214722 | 0.63 | MAP4K1 (0.81) | MAP4K1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022147622-A1 | ISOINDOLINONE AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF NUAK KINASES, COMPOSITIONS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-07-14 | — | — | WO | disclosed |