SCHEMBL24622941

SCHEMBL24622941

O=[N+]([O-])c1cccc(Oc2nc(Cl)nc3c2COC3)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 1/20 0.44
PIN1 Q13526 3/20 0.42
F10 P00742 1/20 0.40
CHRNB2 P17787 1/20 0.40
CHRNA4 P43681 1/20 0.40
LMNA P02545 3/20 0.39
TSHR P16473 1/20 0.39
ALDH1A1 P00352 2/20 0.39
HPGD P15428 2/20 0.39
EGFR P00533 1/20 0.39
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39
KMT2A Q03164 1/20 0.39
SLC6A2 P23975 1/20 0.38
SLC6A4 P31645 1/20 0.38
SLC6A3 Q01959 1/20 0.38
CHRNB4 P30926 1/20 0.38
CHRNA3 P32297 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
LTA4H P09960 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29809880 1.00 ABCG2 (0.44) ABCG2PIN1F10CHRNB2CHRNA4
SCHEMBL2014375 0.74 ABCG2 (0.72) ABCG2PIN1F10LMNAALDH1A1
SCHEMBL12519771 0.74 PIN1 (0.57) ABCG2PIN1F10LMNAALDH1A1
SCHEMBL14914947 0.74 ABCG2 (0.50) ABCG2PIN1F10CHRNB2CHRNA4
SCHEMBL1706682 0.73 PIN1 (0.59) ABCG2PIN1F10CHRNB2CHRNA4
SCHEMBL24623410 0.73 EGFR (0.54) ALDH1A1EGFRMAPTSLC6A2SLC6A3
SCHEMBL21358342 0.71 PIN1 (0.57) ABCG2PIN1F10CHRNB2CHRNA4
SCHEMBL12371194 0.71 ABCG2 (0.53) ABCG2PIN1F10LMNAALDH1A1
SCHEMBL12073508 0.71 ABCG2 (0.47) ABCG2PIN1F10LMNAALDH1A1
SCHEMBL15459970 0.71 ABCG2 (0.50) ABCG2PIN1F10LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022149856-A1 COMPOUND FOR INHIBITING BRUTON'S TYROSINE KINASE, AND PHARMACEUTICAL USE THEREOF 주식회사 온코빅스 2022-07-14 WO disclosed