Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.38 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368951 | 0.93 | KCNH2 (0.41) | KCNH2CYP2C8HPGDCYP3A4 | |
| SCHEMBL253936 | 0.81 | KCNH2 (0.47) | DDR2HIPK4KCNH2CYP2C8 | |
| SCHEMBL244486 | 0.77 | KCNH2 (0.41) | DDR2HIPK4SCN4AKCNH2CYP2C8 | |
| SCHEMBL9947767 | 0.74 | KCNH2 (0.41) | DDR2HIPK4KCNH2CYP2C8ANO1 | |
| SCHEMBL2436747 | 0.73 | AR (0.45) | KCNH2CYP2C8HPGDCYP3A4 | |
| SCHEMBL16113969 | 0.73 | KCNH2 (0.40) | KCNH2CYP2C8ANO1CYP3A4 | |
| SCHEMBL2369389 | 0.73 | CYP3A4 (0.44) | KCNH2CYP2C8ANO1HPGDCYP3A4 | |
| SCHEMBL1918982 | 0.72 | KCNH2 (0.52) | KCNH2CYP2C8 | |
| SCHEMBL19197887 | 0.72 | KCNH2 (0.50) | KCNH2CYP2C8CYP3A4 | |
| SCHEMBL2842305 | 0.72 | CYP3A4 (0.54) | KCNH2CYP2C8ANO1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588464-A1 | BENZOFURAN DERIVATIVES FOR THE TREATMENT OF HEPATITS C | Bristol-Myers Squibb Company (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003164-A1 | BENZOFURAN DERIVATIVES FOR THE TREATMENT OF HEPATITS C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-01-05 | — | — | WO | disclosed |