Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6128121 | 0.73 | KDM4E (0.62) | TRPV1KDM4EHSD17B10LMNAGAA | |
| SCHEMBL27057151 | 0.73 | TRPV1 (0.52) | TRPV1KDM4EHSD17B10LMNAGAA | |
| SCHEMBL29663397 | 0.71 | KDM4E (0.39) | TRPV1KDM4EHSD17B10LMNAGAA | |
| SCHEMBL24625297 | 0.71 | KDM4E (0.39) | TRPV1KDM4EHSD17B10LMNAGAA | |
| SCHEMBL9817824 | 0.71 | KDM4E (0.59) | TRPV1KDM4EHSD17B10LMNAGAA | |
| SCHEMBL29789417 | 0.71 | TRPV1 (0.49) | TRPV1KDM4EHSD17B10LMNAGAA | |
| SCHEMBL27057129 | 0.70 | MEN1 (0.49) | TRPV1KDM4EHSD17B10LMNAGAA | |
| SCHEMBL27057164 | 0.70 | TRPV1 (0.48) | TRPV1KDM4EHSD17B10LMNAGAA | |
| SCHEMBL20327078 | 0.69 | KDM4E (0.56) | TRPV1KDM4EHSD17B10LMNAGAA | |
| SCHEMBL23520600 | 0.69 | KDM4E (0.56) | TRPV1KDM4EHSD17B10LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022148442-A1 | 6-SUBSTITUTED PHOSPHORYL QUINAZOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-07-14 | — | — | WO | disclosed |
| CN-114716478-A | 6-substituted phosphoryl quinazoline derivative and preparation method and application thereof | 武汉人福创新药物研发中心有限公司 | 2022-07-08 | — | — | CN | disclosed |