Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 4/20 | 0.35 |
| ▸ | EZH2 | Q15910 | 4/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24625297 | 1.00 | KDM4E (0.39) | KDM4ENPC1USP2ALDH1A1GLA | |
| SCHEMBL23520707 | 0.85 | SOS1 (0.47) | KDM4EGAALMNAHSD17B10SOS1 | |
| SCHEMBL20327082 | 0.85 | SOS1 (0.47) | KDM4EGAALMNAHSD17B10SOS1 | |
| SCHEMBL24625620 | 0.83 | KDM4E (0.39) | KDM4ENPC1USP2ALDH1A1GLA | |
| SCHEMBL30524585 | 0.83 | KDM4E (0.40) | KDM4ENPC1USP2ALDH1A1GLA | |
| SCHEMBL28779922 | 0.83 | KDM4E (0.40) | KDM4ENPC1USP2ALDH1A1GLA | |
| SCHEMBL28779926 | 0.83 | KDM4E (0.40) | KDM4ENPC1USP2ALDH1A1GLA | |
| SCHEMBL29901682 | 0.72 | PARP1 (0.37) | SOS1EZH2TRPV1PDE4APDE4B | |
| SCHEMBL24792664 | 0.72 | SOS1 (0.46) | KDM4EGAASOS1PDE4APDE4B | |
| SCHEMBL30170826 | 0.72 | SOS1 (0.46) | KDM4EGAASOS1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022148442-A1 | 6-SUBSTITUTED PHOSPHORYL QUINAZOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-07-14 | — | — | WO | disclosed |
| CN-114716478-A | 6-substituted phosphoryl quinazoline derivative and preparation method and application thereof | 武汉人福创新药物研发中心有限公司 | 2022-07-08 | — | — | CN | disclosed |