Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KMT5A | Q9NQR1 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 2/20 | 0.52 |
| ▸ | NPY1R | P25929 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3645747 | 0.90 | APP (0.65) | HRH4LMNAPOLBKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL3640596 | 0.89 | APP (0.64) | HRH4LMNAPOLBKDM4EMAPT | |
| SCHEMBL3642691 | 0.89 | HRH4 (0.66) | HRH4LMNAPOLBKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL3641028 | 0.88 | HRH4 (0.65) | HRH4LMNAPOLBKDM4EMAPT | |
| SCHEMBL3640907 | 0.86 | HRH4 (0.78) | HRH4LMNAKDM4EMAPTGAA | |
| SCHEMBL29777972 | 0.86 | HRH4 (0.78) | HRH4LMNAKDM4EMAPTGAA | |
| SCHEMBL21225645 | 0.85 | HRH4 (0.80) | HRH4LMNAKDM4EMAPTGAA | |
| SCHEMBL3639965 | 0.84 | HRH4 (0.60) | HRH4LMNAPOLBKDM4EMAPT | |
| SCHEMBL14503196 | 0.82 | NPSR1 (0.70) | LMNAPOLBMAPTGAANPSR1 | |
| Anisole SCHEMBL27808580 | 0.82 | KDM4E (0.61) | HRH4LMNAPOLBKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022148879-A1 | QUINAZOLINE DERIVATIVES USEFUL AS MODULATORS OF ACKR3 | STICHTING VU (NL) | 2022-07-14 | — | — | WO | disclosed |