Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GRN | P28799 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 4/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | DBH | P09172 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | MIF | P14174 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26241947 | 0.80 | KDM4E (0.40) | KDM4EGRNSORT1PHGDHMEN1 | |
| SCHEMBL8014330 | 0.79 | SMN1; SMN2 (0.43) | KDM4EGRNSORT1FFAR1GAA | |
| SCHEMBL3760854 | 0.79 | KDM4E (0.39) | KDM4EGRNSORT1PHGDHMEN1 | |
| SCHEMBL1663229 | 0.79 | GRN (0.56) | KDM4EGRNSORT1PHGDHGAA | |
| SCHEMBL2481607 | 0.76 | ALDH1A1 (0.38) | KDM4EGRNSORT1GAAALDH1A1 | |
| SCHEMBL26540840 | 0.75 | CCNE1 (0.35) | KDM4EGRNSORT1PHGDHFFAR1 | |
| SCHEMBL20646935 | 0.75 | GRN (0.67) | KDM4EGRNSORT1TSHR | |
| SCHEMBL15182318 | 0.74 | KDM4E (0.36) | KDM4EGRNSORT1ADORA1 | |
| SCHEMBL17662694 | 0.74 | KDM4E (0.36) | KDM4EGRNSORT1MEN1ALDH1A1 | |
| SCHEMBL22424005 | 0.74 | BAZ2B (0.47) | KDM4EGRNSORT1PHGDHMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022150555-A2 | METHODS AND COMPOUNDS FOR TREATING FRIEDREICH'S ATAXIA | Design Therapeutics, Inc. (US) | 2022-07-14 | — | — | WO | disclosed |