Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 17/20 | 0.73 |
| ▸ | THRA | P10827 | 16/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21286691 | 0.93 | THRB (0.72) | THRBTHRA | |
| SCHEMBL21286640 | 0.93 | THRB (0.72) | THRBTHRA | |
| SCHEMBL21286641 | 0.93 | THRB (0.72) | THRBTHRA | |
| SCHEMBL21286586 | 0.92 | THRB (0.70) | THRBTHRA | |
| SCHEMBL21286550 | 0.91 | THRB (0.74) | THRBTHRAHPGD | |
| Abx-002 SCHEMBL19634315 | 0.89 | THRB (0.79) | THRBTHRA | |
| SCHEMBL21286638 | 0.89 | THRB (0.72) | THRBTHRAALDH1A1 | |
| SCHEMBL21286552 | 0.89 | THRB (0.72) | THRBTHRA | |
| SCHEMBL21286582 | 0.88 | THRB (0.78) | THRBTHRA | |
| SCHEMBL21286510 | 0.88 | THRB (0.70) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4333844-A1 | FATTY ACID AMIDE HYDROLASE (FAAH) CLEAVABLE PRODRUGS OF THYROMIMETICS AND COMBINATION WITH PERIPHERALLY RESTRICTED FAAH INHIBITORS | Autobahn Therapeutics, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| CN-117597122-A | Fatty Acid Amide Hydrolase (FAAH) cleavable prodrugs of thyromimetics and combinations with peripherally restricted FAAH inhibitors | 速通医疗公司 | 2024-02-23 | — | — | CN | disclosed |
| WO-2022236133-A1 | FATTY ACID AMIDE HYDROLASE (FAAH) CLEAVABLE PRODRUGS OF THYROMIMETICS AND COMBINATION WITH PERIPHERALLY RESTRICTED FAAH INHIBITORS | AUTOBAHN THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |
| WO-2022236133-A1 | FATTY ACID AMIDE HYDROLASE (FAAH) CLEAVABLE PRODRUGS OF THYROMIMETICS AND COMBINATION WITH PERIPHERALLY RESTRICTED FAAH INHIBITORS | AUTOBAHN THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |