Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24633865 | 0.91 | MDM4 (0.42) | MDM4TP53MDM2PTPN1 | |
| SCHEMBL29633735 | 0.91 | MDM4 (0.42) | MDM4TP53MDM2PTPN1 | |
| SCHEMBL28741485 | 0.91 | MDM4 (0.42) | MDM4TP53MDM2PTPN1 | |
| SCHEMBL29633743 | 0.91 | MDM4 (0.41) | MDM4TP53MDM2PTPN1 | |
| SCHEMBL24633884 | 0.91 | MDM4 (0.41) | MDM4TP53MDM2PTPN1 | |
| SCHEMBL28741600 | 0.91 | MDM4 (0.41) | MDM4TP53MDM2PTPN1 | |
| SCHEMBL29277303 | 0.90 | MDM2 (0.49) | MDM4TP53MDM2PTPN1 | |
| SCHEMBL29277300 | 0.90 | MDM2 (0.49) | MDM4TP53MDM2PTPN1 | |
| SCHEMBL28741599 | 0.87 | MDM2 (0.46) | MDM4TP53MDM2 | |
| SCHEMBL29633711 | 0.87 | MDM2 (0.46) | MDM4TP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022234853-A1 | CYCLIC COMPOUND HAVING INHIBITORY EFFECT SELECTIVE FOR KRAS BUT NOT FOR HRAS AND NRAS | 中外製薬株式会社 | 2022-11-10 | — | — | WO | disclosed |