Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 8/20 | 0.78 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.78 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.78 |
| ▸ | IARS2 | Q9NSE4 | 1/20 | 0.78 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | ACVR1B | P36896 | 3/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22039304 | 1.00 | MAP2K1 (0.78) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| SCHEMBL14684301 | 1.00 | MAP2K1 (0.78) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| Pimasertib SCHEMBL2021184 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| Pimasertib SCHEMBL29604438 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| Pimasertib SCHEMBL22046269 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| Pimasertib SCHEMBL2720659 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| Pimasertib SCHEMBL29358435 | 0.88 | MAP2K1 (1.00) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| Pimasertib SCHEMBL18260054 | 0.87 | MAP2K1 (0.98) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| Pimasertib SCHEMBL29867955 | 0.87 | MAP2K1 (0.98) | MAP2K1MAP2K2PRKCZIARS2PDE10A | |
| SCHEMBL15233262 | 0.85 | MAP2K1 (0.57) | MAP2K1MAP2K2PRKCZIARS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212568-A9 | COMPOUNDS AND COMPOSITIONS FOR MODULATING LIPID METABOLISM | 1BASE PHARMACEUTICALS, LLC (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2022212568-A1 | COMPOUNDS AND COMPOSITIONS FOR MODULATING LIPID METABOLISM | 1BASE PHARMACEUTICALS, LLC (US) | 2022-10-06 | — | — | WO | disclosed |