SCHEMBL246368

SCHEMBL246368

Nc1nc(Cl)ncc1Br

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31259503 1.00
SCHEMBL29364685 0.75
SCHEMBL30151389 0.75
SCHEMBL1428398 0.75
SCHEMBL338455 0.75
SCHEMBL25247012 0.75
SCHEMBL217854 0.75
SCHEMBL30519373 0.75
SCHEMBL31180013 0.75
SCHEMBL109855 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 408 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117903147-A Preparation method of treasipril and intermediate thereof 沈阳药科大学 2024-04-19 CN claimed
EP-4293029-B1 AZAHETEROARYL COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF SHANGHAI BLUERAY BIOPHARMA CO LTD (CN) 2025-12-17 EP disclosed
US-20250368667-A1 USP1 INHIBITOR SHANGHAI QILU PHARMACEUTICAL RES AND DEVELOPMENT CENTRE LTD (CN) 2025-12-04 US disclosed
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2025-10-02 US disclosed
EP-4582427-A1 USP1 INHIBITOR Shanghai Qilu Pharmaceutical Research and Development Centre Ltd. (CN) 2025-07-09 EP disclosed
CN-120202201-A Inhibitors of ubiquitin-specific protease 1 and uses thereof 深圳晶泰科技有限公司 2025-06-24 CN disclosed
EP-4565588-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF Suzhou Keen Therapeutics Co., Ltd. (CN) 2025-06-11 EP disclosed
US-12281118-B2 Nitrogen-containing fused heterocyclic SHP2 inhibitor compound, preparation method, and use SHANGHAI RINGENE BIOPHARMA CO., LTD. (CN) 2025-04-22 US disclosed
CN-119497713-A USP1 inhibitors 上海齐鲁制药研究中心有限公司 2025-02-21 CN disclosed
CN-118834207-A Synthesis method of 2-chloro-8-cyclopentyl-5-methyl-8H-pyrido [2,3-D ] pyrimidinyl-7-ketone 安徽大学 2024-10-25 CN disclosed
US-20030044845-A1 Novel therapeutic agents for membrane transporters THERAVANCE BIOPHARMA R&D IP, LLC 2003-03-06 US disclosed
US-6479498-B1 COMPRISE 2-10 SODIUM CHANNEL LIGANDS COVALENTLY CONNECTED BY A LINKER OR LINKERS THERAVANCE, INC. 2002-11-12 US disclosed
US-6420354-B1 Sodium channel drugs and uses ADVANCED MEDICINE, INC. 2002-07-16 US disclosed
WO-1999063984-A9 NOVEL SODIUM CHANNEL DRUGS AND USES 2002-04-25 WO disclosed
WO-1999064045-A9 NOVEL THERAPEUTIC AGENTS FOR MEMBRANE TRANSPORTERS ADVANCED MEDICINE INC (US) 2001-07-05 WO disclosed
EP-1089749-A4 NOVEL THERAPEUTIC AGENTS FOR MEMBRANE TRANSPORTERS ADVANCED MEDICINE INC (US) 2001-04-11 EP disclosed
EP-1089749-A1 NOVEL THERAPEUTIC AGENTS FOR MEMBRANE TRANSPORTERS Advanced Medicine, Inc. (US) 2001-04-11 EP disclosed
EP-1085890-A1 NOVEL SODIUM CHANNEL DRUGS AND USES Advanced Medicine, Inc. (US) 2001-03-28 EP disclosed
WO-1999063984-A1 NOVEL SODIUM CHANNEL DRUGS AND USES ADVANCED MEDICINE, INC. (US) 1999-12-16 WO disclosed
WO-1999064045-A1 NOVEL THERAPEUTIC AGENTS FOR MEMBRANE TRANSPORTERS ADVANCED MEDICINE, INC. (US) 1999-12-16 WO disclosed