Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17508483 | 0.86 | HPGD (0.33) | HPGDHSD17B10HTTALOX15GFER | |
| SCHEMBL17508485 | 0.86 | HPGD (0.33) | HPGDHSD17B10HTTALOX15GFER | |
| SCHEMBL17524536 | 0.86 | HPGD (0.33) | HPGDHSD17B10HTTALOX15GFER | |
| SCHEMBL5803088 | 0.73 | HPGD (0.46) | HPGDHSD17B10HTTALOX15GFER | |
| SCHEMBL8697080 | 0.73 | HPGD (0.47) | HPGDHSD17B10HTTALOX15GFER | |
| SCHEMBL8700047 | 0.73 | HPGD (0.47) | HPGDHSD17B10HTTALOX15GFER | |
| SCHEMBL8697082 | 0.73 | HPGD (0.47) | HPGDHSD17B10HTTALOX15GFER | |
| SCHEMBL5803087 | 0.73 | HPGD (0.46) | HPGDHSD17B10HTTALOX15GFER | |
| SCHEMBL1180296 | 0.71 | NPSR1 (0.43) | HTTSMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL1180294 | 0.71 | NPSR1 (0.43) | HTTSMN1; SMN2LMNAMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704114-B1 | SPIROCYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2022-11-23 | — | — | EP | disclosed |