Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | ACACB | O00763 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.34 |
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.33 |
| ▸ | OGA | O60502 | 4/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24639871 | 0.90 | HRH3 (0.37) | NR1H2NR1H3HRH3ACACBCHRM2 | |
| SCHEMBL24639851 | 0.84 | HRH3 (0.36) | NR1H2NR1H3HRH3ACACBCHRM2 | |
| SCHEMBL24639861 | 0.84 | HRH3 (0.36) | NR1H2NR1H3HRH3ACACBCHRM2 | |
| SCHEMBL24640011 | 0.80 | TIPARP (0.40) | NR1H2NR1H3HRH3ACACBMDM2 | |
| SCHEMBL24640002 | 0.80 | TIPARP (0.40) | NR1H2NR1H3HRH3ACACBMDM2 | |
| SCHEMBL24639855 | 0.80 | ACACB (0.40) | NR1H2NR1H3HRH3ACACBMDM2 | |
| SCHEMBL24639836 | 0.80 | HRH3 (0.35) | NR1H2NR1H3HRH3ACACBCHRM2 | |
| SCHEMBL24639864 | 0.79 | HRH3 (0.33) | NR1H2NR1H3HRH3ACACBCHRM2 | |
| SCHEMBL24639834 | 0.79 | CHRM2 (0.34) | NR1H2NR1H3HRH3ACACBCHRM2 | |
| SCHEMBL24640762 | 0.77 | HRH3 (0.36) | NR1H2NR1H3HRH3ACACBCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |