Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 12/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 3/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24640391 | 1.00 | NPBWR1 (0.44) | NPBWR1MCHR1TIPARPPARP2RAF1 | |
| SCHEMBL24639950 | 1.00 | NPBWR1 (0.44) | NPBWR1MCHR1TIPARPPARP2RAF1 | |
| SCHEMBL24639962 | 0.94 | NPBWR1 (0.43) | NPBWR1MCHR1RAF1CCNB2CCNE2 | |
| SCHEMBL24639953 | 0.94 | NPBWR1 (0.43) | NPBWR1MCHR1RAF1CCNB2CCNE2 | |
| SCHEMBL24639955 | 0.94 | NPBWR1 (0.43) | NPBWR1MCHR1RAF1CCNB2CCNE2 | |
| SCHEMBL24763905 | 0.93 | NPBWR1 (0.44) | NPBWR1MCHR1TIPARPPARP2RAF1 | |
| SCHEMBL23297051 | 0.92 | NPBWR1 (0.44) | NPBWR1MCHR1RAF1CCNB2CCNE2 | |
| SCHEMBL23297046 | 0.92 | NPBWR1 (0.44) | NPBWR1MCHR1RAF1CCNB2CCNE2 | |
| SCHEMBL24640392 | 0.91 | NPBWR1 (0.44) | NPBWR1MCHR1TIPARPPARP2 | |
| SCHEMBL21522522 | 0.91 | NPBWR1 (0.44) | NPBWR1MCHR1TIPARPPARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |