Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 14/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BPTF | Q12830 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24640411 | 1.00 | NPBWR1 (0.46) | NPBWR1MCHR1BRD4ALDH1A1HTT | |
| SCHEMBL24640396 | 0.92 | NPBWR1 (0.43) | NPBWR1MCHR1BRD4ALDH1A1HTT | |
| SCHEMBL24640380 | 0.92 | NPBWR1 (0.43) | NPBWR1MCHR1BRD4ALDH1A1HTT | |
| SCHEMBL24640974 | 0.92 | NPBWR1 (0.43) | NPBWR1MCHR1BRD4ALDH1A1HTT | |
| SCHEMBL24640401 | 0.89 | NPBWR1 (0.43) | NPBWR1MCHR1BRD4ALDH1A1HTT | |
| SCHEMBL29731631 | 0.88 | NPBWR1 (0.42) | NPBWR1MCHR1BRD4ALDH1A1HTT | |
| SCHEMBL24640392 | 0.88 | NPBWR1 (0.44) | NPBWR1MCHR1 | |
| SCHEMBL21522519 | 0.88 | NPBWR1 (0.44) | NPBWR1MCHR1 | |
| SCHEMBL21522522 | 0.88 | NPBWR1 (0.44) | NPBWR1MCHR1 | |
| SCHEMBL26914933 | 0.88 | NPBWR1 (0.41) | NPBWR1MCHR1BRD4ALDH1A1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |