Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | BCL6 | P41182 | 1/20 | 0.32 |
| ▸ | WEE1 | P30291 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24640258 | 1.00 | KRAS (0.36) | KRASSOS1AXLBCL6WEE1 | |
| SCHEMBL24640631 | 0.88 | SOS1 (0.35) | SOS1BCL6 | |
| SCHEMBL24640718 | 0.84 | AXL (0.35) | KRASSOS1AXL | |
| SCHEMBL24640208 | 0.84 | AXL (0.35) | KRASSOS1AXL | |
| SCHEMBL24640720 | 0.84 | OPRL1 (0.33) | — | |
| SCHEMBL31244729 | 0.78 | HTR2C (0.42) | — | |
| SCHEMBL24069950 | 0.74 | AXL (0.37) | KRASSOS1AXLBCL6 | |
| SCHEMBL24640606 | 0.73 | SOS1 (0.39) | SOS1AXL | |
| SCHEMBL24675019 | 0.73 | HTR2A (0.34) | KRASSOS1AXLWEE1 | |
| SCHEMBL24675018 | 0.73 | HTR2A (0.34) | KRASSOS1AXLWEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |