Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 6/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 4/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24640355 | 1.00 | TIPARP (0.47) | TIPARPMDM2LMNAALDH1A1HTT | |
| SCHEMBL26958203 | 0.88 | TIPARP (0.48) | TIPARPMDM2LMNAALDH1A1HTT | |
| SCHEMBL24640010 | 0.84 | TIPARP (0.48) | TIPARPMDM2LMNAALDH1A1HTT | |
| SCHEMBL24639999 | 0.84 | TIPARP (0.48) | TIPARPMDM2LMNAALDH1A1HTT | |
| SCHEMBL26915091 | 0.83 | TIPARP (0.55) | TIPARPMDM2LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL29841857 | 0.83 | TIPARP (0.55) | TIPARPMDM2LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL26914953 | 0.83 | TIPARP (0.55) | TIPARPMDM2LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL24640906 | 0.83 | TIPARP (0.37) | TIPARPMDM2LMNAALDH1A1HTT | |
| SCHEMBL24639919 | 0.81 | TIPARP (0.53) | TIPARPMDM2LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL24639921 | 0.81 | TIPARP (0.53) | TIPARPMDM2LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |