Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24640052 | 0.85 | TIPARP (0.38) | TIPARPLMNAALDH1A1HTTCXCR3 | |
| SCHEMBL24640020 | 0.85 | TIPARP (0.38) | TIPARPLMNAALDH1A1HTTCXCR3 | |
| SCHEMBL24640039 | 0.85 | TIPARP (0.38) | TIPARPLMNAALDH1A1HTTCXCR3 | |
| SCHEMBL29088844 | 0.84 | TIPARP (0.42) | TIPARPLMNASMN1; SMN2KMT2AMDM2 | |
| SCHEMBL24640367 | 0.83 | TIPARP (0.47) | TIPARPLMNAALDH1A1HTTCXCR3 | |
| SCHEMBL24640355 | 0.83 | TIPARP (0.47) | TIPARPLMNAALDH1A1HTTCXCR3 | |
| SCHEMBL24675215 | 0.81 | TIPARP (0.42) | TIPARPLMNASMN1; SMN2KMT2A | |
| SCHEMBL24674970 | 0.80 | HTR2C (0.48) | TIPARPLMNAALDH1A1HTT | |
| SCHEMBL24640555 | 0.80 | TIPARP (0.48) | TIPARP | |
| SCHEMBL24675068 | 0.76 | HTR2A (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |