Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 13/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 3/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23297166 | 0.91 | NPBWR1 (0.48) | NPBWR1MCHR1RAF1CCNB2CCNE2 | |
| SCHEMBL23297169 | 0.91 | NPBWR1 (0.48) | NPBWR1MCHR1RAF1CCNB2CCNE2 | |
| SCHEMBL21521225 | 0.88 | NPBWR1 (0.51) | NPBWR1MCHR1RAF1CCNB2CCNE2 | |
| SCHEMBL21521227 | 0.88 | NPBWR1 (0.51) | NPBWR1MCHR1RAF1CCNB2CCNE2 | |
| SCHEMBL24640479 | 0.88 | NPBWR1 (0.51) | NPBWR1MCHR1RAF1CCNB2CCNE2 | |
| SCHEMBL24639955 | 0.85 | NPBWR1 (0.43) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL24639962 | 0.85 | NPBWR1 (0.43) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL24639953 | 0.85 | NPBWR1 (0.43) | NPBWR1MCHR1PDE1APDE1BPDE1C | |
| SCHEMBL24675536 | 0.85 | NPBWR1 (0.48) | NPBWR1MCHR1RAF1CCNB2CCNE2 | |
| SCHEMBL23297161 | 0.83 | NPBWR1 (0.50) | NPBWR1MCHR1RAF1CCNB2CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |