Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.37 |
| ▸ | TIPARP | Q7Z3E1 | 11/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.35 |
| ▸ | GRM5 | P41594 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24640360 | 1.00 | HTR2A (0.38) | HTR2AHTR2CHTR2BSOS1TIPARP | |
| SCHEMBL24675032 | 0.87 | HTR2A (0.34) | HTR2AHTR2CHTR2BSOS1TIPARP | |
| SCHEMBL24675019 | 0.87 | HTR2A (0.34) | HTR2AHTR2CHTR2BSOS1TIPARP | |
| SCHEMBL24675018 | 0.87 | HTR2A (0.34) | HTR2AHTR2CHTR2BSOS1TIPARP | |
| SCHEMBL24675045 | 0.86 | HTR2A (0.37) | HTR2AHTR2CHTR2BSOS1TIPARP | |
| SCHEMBL24675043 | 0.86 | HTR2A (0.37) | HTR2AHTR2CHTR2BSOS1TIPARP | |
| SCHEMBL24640827 | 0.84 | NLRP3 (0.42) | SOS1TIPARPPARP2GRM5CYP3A4 | |
| SCHEMBL24640620 | 0.84 | TIPARP (0.47) | HTR2AHTR2CHTR2BTIPARPPARP2 | |
| SCHEMBL24639353 | 0.84 | SOS1 (0.41) | SOS1TIPARPPARP2OPRK1 | |
| SCHEMBL24639358 | 0.84 | SOS1 (0.41) | SOS1TIPARPPARP2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022170974-A1 | TRICYCLIC DERIVATIVES USEFUL AS PARP7 INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-08-18 | — | — | WO | disclosed |