⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL181757 | 0.72 | — | — | |
| SCHEMBL12306156 | 0.71 | — | — | |
| SCHEMBL4011447 | 0.71 | — | — | |
| SCHEMBL22845671 | 0.53 | — | — | |
| SCHEMBL6425188 | 0.47 | — | — | |
| SCHEMBL4651720 | 0.47 | FKBP5 (0.33) | — | |
| SCHEMBL940079 | 0.46 | — | — | |
| SCHEMBL5241396 | 0.45 | — | — | |
| SCHEMBL12800325 | 0.44 | — | — | |
| SCHEMBL8262750 | 0.43 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679796-A | Process for the preparation of 2-chloro-5-chloromethylthiazole | BAYER AKTIENGESELLSCHAFT (DE) | 1997-10-21 | — | — | US | claimed |
| EP-0780384-A2 | Process for the production of 2-chloro-5-chloromethylthiazole | BAYER AG (DE) | 1997-06-25 | — | — | EP | claimed |
| JP-9176140-A | — | — | None | — | — | JP | disclosed |
| CN-118847007-A | Reaction kettle for thiazole production | 汪盈盈 | 2024-10-29 | — | — | CN | disclosed |
| WO-2021117014-A2 | SMALL MOLECULE INHIBITORS OF FUNGAL HYPHAE AND BIOFILM FORMATION | UNIVERSITY OF SHARJAH (AE) | 2021-06-17 | — | — | WO | disclosed |
| CN-210974472-U | Preparation facilities of 2, 3-dichloropropene compound | 湖南莱万特化工有限公司 | 2020-07-10 | — | — | CN | disclosed |
| US-20110306772-A1 | PROCESS FOR THE PREPARATION OF 2-CHLORO-5-CHLOROMETHYL-THIAZOLE | SYNGENTA CROP PROTECTION LLC (US) | 2011-12-15 | — | — | US | disclosed |
| US-20110306772-A1 | PROCESS FOR THE PREPARATION OF 2-CHLORO-5-CHLOROMETHYL-THIAZOLE | SYNGENTA CROP PROTECTION LLC (US) | 2011-12-15 | — | — | US | disclosed |
| US-20110306772-A1 | PROCESS FOR THE PREPARATION OF 2-CHLORO-5-CHLOROMETHYL-THIAZOLE | SYNGENTA CROP PROTECTION LLC (US) | 2011-12-15 | — | — | US | disclosed |
| US-8013167-B1 | Process for the preparation of 2-chloro-5-chloromethyl-thiazole | SYNGENTA CROP PROTECTION, INC. (US) | 2011-09-06 | — | — | US | disclosed |
| US-20110082134-A1 | 1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia | ARENA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | US | disclosed |
| EP-0873326-A1 | PROCESS FOR PREPARING 2-CHLOROTHIAZOLE COMPOUNDS | Novartis AG (CH) | 1998-10-28 | — | — | EP | disclosed |
| US-5679796-A | Process for the preparation of 2-chloro-5-chloromethylthiazole | BAYER AKTIENGESELLSCHAFT (DE) | 1997-10-21 | — | — | US | disclosed |
| US-5679796-A | Process for the preparation of 2-chloro-5-chloromethylthiazole | BAYER AKTIENGESELLSCHAFT (DE) | 1997-10-21 | — | — | US | disclosed |
| CN-1157284-A | Process for preparation of 3-chloro-5-chlormethylthiazole | BAYER AG (DE) | 1997-08-20 | — | — | CN | disclosed |
| JP-H09176140-A | PRODUCTION OF 2-CHLORO-5-CHLOROMETHYLTHIAZOLE | BAYER AG | 1997-07-08 | — | — | JP | disclosed |
| WO-1997023469-A1 | PROCESS FOR THE PREPARATION OF 2-CHLORO-5-CHLOROMETHYL-THIAZOLE | NOVARTIS AG (CH) | 1997-07-03 | — | — | WO | disclosed |
| EP-0780384-A2 | Process for the production of 2-chloro-5-chloromethylthiazole | BAYER AG (DE) | 1997-06-25 | — | — | EP | disclosed |
| EP-0780384-A2 | Process for the production of 2-chloro-5-chloromethylthiazole | BAYER AG (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1997020829-A1 | PROCESS FOR PREPARING 2-CHLOROTHIAZOLE COMPOUNDS | NOVARTIS AG (CH) | 1997-06-12 | — | — | WO | disclosed |