FKBP5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1101756	0.61	19/20
SCHEMBL1107277	0.60	19/20
SCHEMBL1099164	0.58	19/20
SCHEMBL1099974	0.55	19/20
SCHEMBL1107265	0.77	18/20
SCHEMBL1107268	0.59	18/20
SCHEMBL1107276	0.59	18/20
SCHEMBL1124338	0.59	18/20
SCHEMBL3429958	0.52	18/20
SCHEMBL1107263	0.89	17/20
SCHEMBL2678953	0.73	17/20
SCHEMBL1107264	0.72	17/20
SCHEMBL1107272	0.72	17/20
SCHEMBL1124268	0.72	17/20
SCHEMBL1098513	0.63	17/20
SCHEMBL1098516	0.63	17/20
SCHEMBL611146	0.51	15/20
SCHEMBL611147	0.51	15/20
SCHEMBL609094	0.48	14/20
SCHEMBL609095	0.48	14/20

Clinical trials — most relevant to FKBP5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Topical Metformin Emulgel VS Salicylic Acid Peeling in Treatment of Acne Vulgaris	PHASE4	UNKNOWN
Utilising Genotype Informed Bayesian Dosing of Tacrolimus in Children Post Solid Organ Transplantation.	PHASE4	RECRUITING
Rapamycin for Immunosuppression and B Cell Modulation Post Stem Cell Transplant for Acute Lymphoblastic Leukemia (ALL)	PHASE2	COMPLETED
Neurosteroids for PTSD in Veterans	PHASE2	COMPLETED
FK506 (Tacrolimus) in Pulmonary Arterial Hypertension	PHASE2	COMPLETED
Temsirolimus With or Without Megestrol Acetate and Tamoxifen Citrate in Treating Patients With Advanced, Persistent, or Recurrent Endometrial Cancer	PHASE2	COMPLETED
A Phase I Study of IMC-A12 in Combination With Temsirolimus in Pediatric Patients With Recurrent or Refractory Solid Tumors	PHASE1	WITHDRAWN
FKBP5 Methylation and Childhood Emotional Abuse in Complex Posttraumatic Stress Disorder: Investigating the Relationship and Its Predictive Role in Therapy Outcome	nan	COMPLETED
Cortisol, Hippocampus, and Insula in Anorexia Nervosa.	nan	RECRUITING
Clinical Implications of FKBP5 in Stroke	nan	UNKNOWN
Poor Sleep During Pregnancy as Risk Factor for Post-partum Stress and Mental Health	nan	RECRUITING
Quantification of GADD34 Expression in RA	nan	COMPLETED
Torisel in Addition to Standard Chemotherapy With Radiation for Advanced Head and Neck Cancer	nan	WITHDRAWN
Genetic Predictors of Lithium Response in Bipolar Disorder	nan	COMPLETED
A Study on Psychopathological Progress of Early Schizophrenia-Like Disorder (SOPRES)	nan	UNKNOWN
Impact of CYP3A5 Gene Polymorphisms on Tacrolimus Concentrations and Outcomes in Thai Transplant Recipients	nan	UNKNOWN
Gene Polymorphisms in Tacrolimus Drug Interactions	nan	COMPLETED
Multi-level Molecular Profiling of High Acute Stress: a Clinical Study	nan	UNKNOWN
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
Post-Deployment Afghanistan/Iraq Trauma Related Inventory of Traits (PATRIOT): Phase 1 (Feasibility Study)	nan	COMPLETED
Study of the Cellular Diffusion of Tacrolimus Across the Membrane of Mononuclear Cells	nan	COMPLETED
Major Depression and Messenger RNAs	nan	COMPLETED
Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia	nan	COMPLETED
Sensorimotor Gating in Schizophrenia	nan	COMPLETED
Effect of Genetic Polymorphism on Calcineurin Inhibitors Levels in Egyptian Renal Transplant Patients	nan	COMPLETED
Investigation of Pain Incidence After FK506 Immunosuppressive Therapy in Liver Transplantation Patients	nan	UNKNOWN
Bipolar Proteomic Assay Validation Study	nan	COMPLETED
Cerebellar Mutism Syndrome Study	nan	RECRUITING
Efficacy of Achieving Early Target Trough Levels of Tacrolimus Using CYP3A5 Guided Dosing Versus Weight-based Dosing in a Multi-ethnic Population of Kidney Transplant Recipients in Singapore	nan	COMPLETED
An Evaluation of Two PTSD Assessments in an Active Duty and Military Veteran Sample	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a FKBP5 binder may also engage these)

Protein	Name	Similarity
Q5RF88	—	1.000	Q5RF88 →
Q95L05	—	1.000	Q95L05 →
Q64378	—	1.000	Q64378 →
Q9XSI2	—	1.000	Q9XSI2 →
Q5U2T9	—	1.000	Q5U2T9 →
Q9XSH5	—	1.000	Q9XSH5 →
Q9XT11	—	1.000	Q9XT11 →
Q9QVC8	—	1.000	Q9QVC8 →
FKBP4	Peptidyl-prolyl cis-trans isomerase FKBP4	0.998	landscape →
P27124	—	0.997	P27124 →
Q9TRY0	—	0.997	Q9TRY0 →
P30416	—	0.997	P30416 →
Q9VL78	—	0.993	Q9VL78 →
Q9FJL3	—	0.991	Q9FJL3 →
Q43207	—	0.989	Q43207 →
Q9JLG9	—	0.987	Q9JLG9 →
Q9ZSV1	—	0.986	Q9ZSV1 →
Q8VY78	—	0.986	Q8VY78 →
P0C1J7	—	0.985	P0C1J7 →
Q5JNB5	—	0.985	Q5JNB5 →
Q95MN8	—	0.985	Q95MN8 →
Q7YRC1	—	0.985	Q7YRC1 →
Q9ZP54	—	0.985	Q9ZP54 →
Q9S7G6	—	0.985	Q9S7G6 →
Q3KRD5	—	0.985	Q3KRD5 →
P39867	—	0.985	P39867 →
Q95MP0	—	0.984	Q95MP0 →
Q5FWY5	—	0.984	Q5FWY5 →
FKBP3	Peptidyl-prolyl cis-trans isomerase FKBP3	0.984	landscape →
Q2NL08	—	0.984	Q2NL08 →