Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 8/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | GFER | P55789 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MPO | P05164 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.32 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL249677 | 0.94 | PIK3CD (0.36) | MAP4K4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL250361 | 0.93 | PIK3CD (0.38) | MAP4K4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL249910 | 0.93 | PIK3CD (0.37) | MAP4K4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL249625 | 0.90 | PIK3CD (0.35) | MAP4K4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL248515 | 0.89 | HTT (0.34) | MAP4K4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL248495 | 0.89 | PIK3CD (0.38) | MAP4K4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL247399 | 0.88 | PIK3CD (0.33) | MAP4K4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL248315 | 0.88 | PIK3CD (0.37) | MAP4K4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL248767 | 0.88 | PIK3CD (0.37) | MAP4K4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL249334 | 0.88 | IP6K1 (0.39) | PIK3CDPIK3CAPIK3CBPIK3CGHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588469-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003271-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |