Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 9/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL249677 | 0.90 | PIK3CD (0.36) | IP6K1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL250361 | 0.89 | PIK3CD (0.38) | HTTLMNASMN1; SMN2MAPTTSHR | |
| SCHEMBL249910 | 0.88 | PIK3CD (0.37) | HTTLMNASMN1; SMN2MAPTTSHR | |
| SCHEMBL246483 | 0.88 | MAP4K4 (0.38) | IP6K1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL249625 | 0.86 | PIK3CD (0.35) | IP6K1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL249593 | 0.86 | HTT (0.34) | HTTLMNASMN1; SMN2MAPTTSHR | |
| SCHEMBL248515 | 0.85 | HTT (0.34) | IP6K1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL248495 | 0.84 | PIK3CD (0.38) | IP6K1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL248311 | 0.83 | MAP4K4 (0.38) | HTTLMNASMN1; SMN2MAPTKDM4E | |
| SCHEMBL248767 | 0.82 | PIK3CD (0.37) | IP6K1HTTLMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588469-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003271-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |