Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465679 | 0.89 | BACE1 (0.61) | BACE1KCNH2BACE2 | |
| SCHEMBL2463159 | 0.80 | BACE1 (0.63) | BACE1KCNH2BACE2RENCTSD | |
| SCHEMBL2086695 | 0.76 | BACE1 (0.64) | BACE1KCNH2BACE2RENCTSD | |
| SCHEMBL2084717 | 0.75 | BACE1 (0.71) | BACE1KCNH2BACE2RENCTSD | |
| SCHEMBL2461170 | 0.73 | BACE1 (0.58) | BACE1KCNH2BACE2RENCTSD | |
| SCHEMBL2087395 | 0.72 | BACE1 (0.60) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL2086155 | 0.72 | BACE1 (0.46) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL3552580 | 0.72 | BACE1 (0.55) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL2086072 | 0.72 | BACE1 (0.49) | BACE1KCNH2BACE2CTSD | |
| SCHEMBL3549935 | 0.71 | BACE1 (0.74) | BACE1KCNH2BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367814-A1 | NEW COMPOUNDS 578 | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010056196-A1 | NEW COMPOUNDS 578 | ASTRAZENECA AB (SE) | 2010-05-20 | — | — | WO | disclosed |