Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.96 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.96 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | BLM | P54132 | 3/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.96 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.96 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.96 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.96 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.96 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.96 |
| ▸ | HTR1A | P08908 | 2/20 | 0.96 |
| ▸ | TSHR | P16473 | 2/20 | 0.96 |
| ▸ | DRD1 | P21728 | 2/20 | 0.96 |
| ▸ | DRD3 | P35462 | 2/20 | 0.96 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.96 |
| ▸ | HTR7 | P34969 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylephrine SCHEMBL30800718 | 1.00 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL21829033 | 1.00 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL29382859 | 1.00 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL412215 | 1.00 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL5053821 | 1.00 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL30104947 | 1.00 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL3643743 | 1.00 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL24654 | 1.00 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL5958774 | 0.98 | HIF1A (0.97) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL4711 | 0.98 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7733 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260130870-A1 | PHENYLEPHRINE LIQUID FORMULATIONS | FRESENIUS KABI AUSTRIA GMBH (AT) | 2026-05-14 | — | — | US | claimed |
| US-12605348-B2 | Pharmaceutical formulations of naproxen for soft gel encapsulation and combinations thereof | CATALENT ONTARIO LIMITED (CA) | 2026-04-21 | — | — | US | claimed |
| US-12564561-B2 | Dilute ready to use large volume containers of phenylephrine | SINTETICA S.A. (CH) | 2026-03-03 | — | — | US | claimed |
| US-12508240-B2 | Liquid composition comprising ibuprofen and phenylephrine | FARMALÍDER, S.A. (ES) | 2025-12-30 | — | — | US | claimed |
| US-20250381201-A1 | COMPOSITIONS AND METHODS FOR TREATING EYES AND METHODS OF PREPARATION | OCULAR SCIENCE INC (US) | 2025-12-18 | — | — | US | claimed |
| US-12490932-B2 | Ophthalmic drug delivery | EYENOVIA, INC. (US) | 2025-12-09 | — | — | US | claimed |
| US-20250325479-A1 | READY-TO-USE PHENYLEPHRINE FORMULATIONS AND PRODUCTS | InfoRLife SA (CH) | 2025-10-23 | — | — | US | claimed |
| US-20250312270-A1 | READY-TO-INFUSE PHENYLEPHRINE COMPOSITIONS | AMNEAL EU, LIMITED (IE) | 2025-10-09 | — | — | US | claimed |
| US-12419959-B2 | Dermal skin protectant and carrier | Inspired Material Strategies, LLC (US) | 2025-09-23 | — | — | US | claimed |
| US-12403103-B2 | Compositions and methods useful for treatment of respiratory illness | THE PROCTER & GAMBLE COMPANY (US) | 2025-09-02 | — | — | US | claimed |
| EP-0046270-B1 | NOVEL DERIVATIVES OF BIO-AFFECTING PHENOLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | INTERx RESEARCH CORPORATION (US) | 1986-05-21 | — | — | EP | claimed |
| US-4576645-A | Whipped gel composition | BLOCK DRUG CO., INC. (US) | 1986-03-18 | — | — | US | claimed |
| EP-0132472-A1 | Medicated products containing a magnesium trisilicate adsorbent with a medicament drug adsorbed thereon | WARNER-LAMBERT COMPANY (US) | 1985-02-13 | — | — | EP | claimed |
| EP-0093373-A1 | Method and composition for treating and preventing irritation of the mucous membranes of the nose | Bernstein, Joel E. (US) | 1983-11-09 | — | — | EP | claimed |
| US-4352789-A | COATING OF PERFLUORINATED SURFACTANT; INHALANTS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1982-10-05 | — | — | US | claimed |
| US-4285967-A | Cosmetic preparation for reducing redness of blemishes | ESTEE LAUDER INC. (US) | 1981-08-25 | — | — | US | claimed |
| US-4265875-A | HYDROXYPROPYL METHYL CELLULOSE | INVERESK RESEARCH INTERNATIONAL (GB) | 1981-05-05 | — | — | US | claimed |
| US-4188373-A | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes | COOPER LABORATORIES, INC. (US) | 1980-02-12 | — | — | US | claimed |
| US-4136173-A | VEHICLES FOR OPHTHALMIC DRUGS | AMERICAN HOME PRODUCTS CORP. (US) | 1979-01-23 | — | — | US | claimed |
| US-3968245-A | Sympathomimetic topical and percutaneous administration with halogenated promoters | ALZA CORPORATION (US) | 1976-07-06 | — | — | US | claimed |