Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.93 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.93 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 0.97 |
| ▸ | BLM | P54132 | 3/20 | 0.97 |
| ▸ | GAA | P10253 | 1/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.93 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.93 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.93 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.93 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.93 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.93 |
| ▸ | HTR1A | P08908 | 2/20 | 0.93 |
| ▸ | TSHR | P16473 | 2/20 | 0.93 |
| ▸ | DRD1 | P21728 | 2/20 | 0.93 |
| ▸ | DRD3 | P35462 | 2/20 | 0.93 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.93 |
| ▸ | HTR7 | P34969 | 1/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylephrine SCHEMBL29382859 | 0.98 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL30800718 | 0.98 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL412215 | 0.98 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL5053821 | 0.98 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL30104947 | 0.98 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL3643743 | 0.98 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL24655 | 0.98 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL24654 | 0.98 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL21829033 | 0.98 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA | |
| Phenylephrine SCHEMBL4711 | 0.96 | HIF1A (1.00) | HIF1AKDM4ELMNABLMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150238615-A1 | Denaturants for sympathomimetic amines | MACKLES LEONARD (US) | 2015-08-27 | — | — | US | disclosed |
| WO-2013089986-A1 | IMPROVED DENATURANTS FOR SYMPATHOMIMETIC AMINES | PRODUCT AND TECHNOLOGY PARTNERS LLC (US) | 2013-06-20 | — | — | WO | disclosed |
| US-8420700-B1 | Tamper resistant lipid-based oral dosage form for sympathomimetic amines | BAUSCH JAMES M (US) | 2013-04-16 | — | — | US | disclosed |
| US-20060216268-A1 | Denaturants for sympathomimetic amine salts | MCNEIL-PPC, INC | 2006-09-28 | — | — | US | disclosed |
| US-20050256194-A1 | Denaturants for sympathomimetic amine salts | MCNEIL-PPC, INC | 2005-11-17 | — | — | US | disclosed |
| US-20020082304-A1 | Denaturants for sympathomimetic amine salts | MCNEIL-PPC, INC | 2002-06-27 | — | — | US | disclosed |
| US-6359011-B1 | EFFECTIVE IN DETERRING EXTRACTION OR CONVERSION METHODS USED IN ILLEGAL DRUG PRODUCTION OF METHAMPHETAMINE FROM PSEUDOEPHEDRINE | WARNER-LAMBERT COMPANY | 2002-03-19 | — | — | US | disclosed |
| EP-1112089-A1 | COMPOSITIONS COMPRISING SYMPATHOMIMETIC AMINE SALTS UNSUITABLE FOR ILLEGAL USE | WARNER-LAMBERT COMPANY (US) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000015261-A1 | COMPOSITIONS COMPRISING SYMPATHOMIMETIC AMINE SALTS UNSUITABLE FOR ILLEGAL USE | WARNER-LAMBERT COMPANY (US) | 2000-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082304-A1 | Denaturants for sympathomimetic amine salts | TAAR5, PNMT, COMT | ADRA1A 133/4885ADRA1B 71/4885ADRA1D 87/4885 |
| US-20050256194-A1 | Denaturants for sympathomimetic amine salts | TAAR5, PNMT, COMT | ADRA1A 133/4885ADRA1B 71/4885ADRA1D 87/4885 |
| US-20060216268-A1 | Denaturants for sympathomimetic amine salts | TAAR5, PNMT, COMT | ADRA1A 133/4885ADRA1B 71/4885ADRA1D 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.