Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465719 | 1.00 | FEN1 (0.41) | FEN1ALOX5APIRAK1CYP2C9KAT6A | |
| SCHEMBL2456779 | 0.94 | FNTA (0.43) | FEN1ALOX5APIRAK1CYP2C9CCNT1 | |
| SCHEMBL2456782 | 0.94 | FNTA (0.43) | FEN1ALOX5APIRAK1CYP2C9CCNT1 | |
| SCHEMBL2465419 | 0.91 | CHEK2 (0.43) | FEN1ALOX5APIRAK1CYP2C9CCNT1 | |
| SCHEMBL2465420 | 0.91 | CHEK2 (0.43) | FEN1ALOX5APIRAK1CYP2C9CCNT1 | |
| SCHEMBL2462554 | 0.91 | IRAK1 (0.42) | FEN1ALOX5APIRAK1CYP2C9CCNT1 | |
| SCHEMBL2460169 | 0.91 | IRAK1 (0.42) | FEN1ALOX5APIRAK1CYP2C9CCNT1 | |
| SCHEMBL2460173 | 0.91 | IRAK1 (0.42) | FEN1ALOX5APIRAK1CYP2C9CCNT1 | |
| SCHEMBL2461542 | 0.86 | FEN1 (0.42) | FEN1ALOX5APIRAK1CYP2C9KAT6A | |
| SCHEMBL2461546 | 0.86 | FEN1 (0.42) | FEN1ALOX5APIRAK1CYP2C9KAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | N.V. ORGANON (NL) | 2011-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218189-A1 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS | PRKCZ, PRKCQ, PRKCD | FEN1 3602/4885ALOX5AP 2869/4885IRAK1 1527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.