SCHEMBL2465822

SCHEMBL2465822

COC(=O)Oc1nc(-c2c(F)cc(C(F)F)c(OC)c2Cl)cc(N)c1Cl

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDCD1LG2 Q9BQ51 1/20 0.30
CD274 Q9NZQ7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2469306 0.89 ILK (0.33) PDCD1LG2CD274
SCHEMBL2467774 0.88 KDM4E (0.33)
SCHEMBL3393072 0.84 NQO2 (0.33)
SCHEMBL2464658 0.84 KDM4E (0.33) PDCD1LG2CD274
SCHEMBL2467726 0.84 PDCD1LG2 (0.31) PDCD1LG2CD274
SCHEMBL27855645 0.83 CYP3A4 (0.30)
SCHEMBL2464806 0.83 PDCD1LG2 (0.38) PDCD1LG2CD274
SCHEMBL2466386 0.82 PDCD1LG2 (0.30) PDCD1LG2CD274
SCHEMBL2466407 0.81 PDCD1LG2 (0.35) PDCD1LG2CD274
SCHEMBL2469762 0.81 ALOX5AP (0.32) PDCD1LG2CD274

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2369929-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
WO-2010060581-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed