Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11875562 | 0.98 | ALDH1A1 (0.50) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| Hydrochloric Acid SCHEMBL29820471 | 0.98 | ALDH1A1 (0.50) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| Isopropylbenzene SCHEMBL7041369 | 0.87 | TAAR1 (0.48) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL11480062 | 0.87 | DPP4 (0.61) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL11478580 | 0.87 | DPP4 (0.61) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| Isopropylbenzene SCHEMBL6568 | 0.84 | — | — | |
| Isopropylbenzene SCHEMBL87809 | 0.84 | TAAR1 (0.50) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| Isopropylbenzene SCHEMBL11254813 | 0.84 | — | — | |
| Isopropylbenzene SCHEMBL8431863 | 0.84 | TAAR1 (0.50) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| Isopropylbenzene SCHEMBL3672803 | 0.84 | TAAR1 (0.50) | ADRA2AADRA2CLMNAHIF1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059665-A1 | DIMERIC COMPOUNDS AS INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2024-03-21 | — | — | WO | disclosed |
| WO-2022198196-A1 | INHIBITORS OF GLYCOGEN SYNTHASE 1 (GYS1) AND METHODS OF USE THEREOF | MAZE THERAPEUTICS, INC. (US) | 2022-09-22 | — | — | WO | disclosed |