Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 14/20 | 0.41 |
| ▸ | SRC | P12931 | 13/20 | 0.41 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24666913 | 0.87 | FGFR1 (0.41) | FGFR1SRCS1PR2CYP11B2BRD4 | |
| SCHEMBL24665079 | 0.84 | FGFR1 (0.45) | FGFR1SRCABL1CYP11B2BRD4 | |
| SCHEMBL24666542 | 0.81 | FGFR1 (0.39) | FGFR1SRCABL1CYP11B2 | |
| SCHEMBL24667330 | 0.81 | FGFR1 (0.41) | FGFR1SRCABL1BRD4 | |
| SCHEMBL24666699 | 0.81 | FGFR1 (0.41) | FGFR1SRCABL1BRD4 | |
| SCHEMBL24665032 | 0.80 | FGFR1 (0.41) | FGFR1SRCABL1CYP11B2EGFR | |
| SCHEMBL24666746 | 0.80 | FGFR1 (0.41) | FGFR1SRCABL1CYP11B2EGFR | |
| SCHEMBL24665033 | 0.80 | FGFR1 (0.41) | FGFR1SRCABL1CYP11B2EGFR | |
| SCHEMBL29977131 | 0.79 | FGFR1 (0.38) | FGFR1SRCCYP11B2 | |
| SCHEMBL24666663 | 0.79 | FGFR1 (0.40) | FGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022236319-A1 | NAPHTHYRIDONE COMPOUNDS FOR INHIBITION OF RAF KINASES AND/OR BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |
| WO-2022236319-A1 | NAPHTHYRIDONE COMPOUNDS FOR INHIBITION OF RAF KINASES AND/OR BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |