Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 15/20 | 0.38 |
| ▸ | SRC | P12931 | 15/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.33 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.33 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.33 |
| ▸ | CCR9 | P51686 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24666732 | 1.00 | FGFR1 (0.38) | FGFR1SRCCYP11B2GABRA1GABRG2 | |
| SCHEMBL24666542 | 0.92 | FGFR1 (0.39) | FGFR1SRCCYP11B2CCR9 | |
| SCHEMBL24667115 | 0.90 | CCR9 (0.35) | FGFR1SRCGABRA1GABRG2GABRB3 | |
| SCHEMBL30884991 | 0.89 | FGFR1 (0.36) | FGFR1SRC | |
| SCHEMBL30884962 | 0.89 | BTK (0.41) | FGFR1SRCCCR9 | |
| SCHEMBL24667279 | 0.88 | KRAS (0.34) | FGFR1SRCGABRA1GABRG2GABRB3 | |
| SCHEMBL29977585 | 0.88 | KRAS (0.34) | FGFR1SRCGABRA1GABRG2GABRB3 | |
| SCHEMBL29977900 | 0.88 | SRC (0.47) | FGFR1SRCGABRA1GABRG2GABRB3 | |
| SCHEMBL24667123 | 0.87 | FGFR1 (0.38) | FGFR1SRC | |
| SCHEMBL29977554 | 0.86 | SRC (0.38) | FGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022236319-A1 | NAPHTHYRIDONE COMPOUNDS FOR INHIBITION OF RAF KINASES AND/OR BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |