Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | UBE2N | P61088 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24559309 | 0.91 | LMNA (0.58) | LMNAMAPK1ABCC8KCNJ11ADORA2B | |
| SCHEMBL24559156 | 0.84 | LMNA (0.49) | LMNAMAPK1ABCC8KCNJ11ADORA2B | |
| SCHEMBL24559151 | 0.79 | LMNA (0.48) | LMNAMAPK1ABCC8KCNJ11ADORA2B | |
| SCHEMBL24666143 | 0.78 | LMNA (0.58) | LMNAMAPK1ABCC8KCNJ11ADORA2B | |
| SCHEMBL24559279 | 0.78 | MYC (0.52) | LMNAMAPK1ABCC8KCNJ11ADORA2B | |
| SCHEMBL24559153 | 0.76 | LMNA (0.51) | LMNAMAPK1ABCC8KCNJ11ADORA2B | |
| SCHEMBL24559268 | 0.74 | LMNA (0.63) | LMNAMAPK1ABCC8KCNJ11ADORA2B | |
| SCHEMBL24559307 | 0.73 | LMNA (0.61) | LMNAMAPK1ABCC8KCNJ11ADORA2B | |
| SCHEMBL24559129 | 0.73 | LMNA (0.60) | LMNAMAPK1ABCC8KCNJ11ADORA2B | |
| SCHEMBL24559245 | 0.72 | LMNA (0.60) | LMNAMAPK1ABCC8KCNJ11ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159818-A1 | POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) INHIBITORS AGAINST COVID MACRODOMAIN AND METHODS OF USING THE SAME | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-07-28 | — | — | WO | disclosed |