Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.77 |
| ▸ | MAOB | P27338 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | KCNQ3 | O43525 | 4/20 | 0.52 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.52 |
| ▸ | KCNE1 | P15382 | 4/20 | 0.52 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.52 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29803768 | 1.00 | MAPT (0.77) | MAPTMAOBNPC1RAB9AMEN1 | |
| SCHEMBL24669338 | 0.89 | MAOB (0.70) | MAPTMAOBNPC1RAB9AMEN1 | |
| SCHEMBL29803408 | 0.89 | MAOB (0.70) | MAPTMAOBNPC1RAB9AMEN1 | |
| SCHEMBL24671107 | 0.89 | MAPT (0.90) | MAPTMAOBNPC1RAB9AMEN1 | |
| SCHEMBL29803936 | 0.89 | MAPT (0.90) | MAPTMAOBNPC1RAB9AMEN1 | |
| SCHEMBL24671323 | 0.85 | MAOB (0.65) | MAPTMAOBNPC1RAB9ALMNA | |
| SCHEMBL24670922 | 0.83 | TP53 (0.63) | MAPTMAOBNPC1RAB9AMEN1 | |
| SCHEMBL29803287 | 0.82 | MAOB (0.59) | MAPTMAOBNPC1RAB9AMEN1 | |
| SCHEMBL24670851 | 0.82 | MAOB (0.59) | MAPTMAOBNPC1RAB9AMEN1 | |
| SCHEMBL24669484 | 0.80 | MAOB (0.59) | MAPTMAOBNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022192162-A1 | NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE | FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) | 2022-09-15 | — | — | WO | disclosed |
| WO-2022192162-A1 | NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE | FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) | 2022-09-15 | — | — | WO | disclosed |