Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 20/20 | 0.49 |
| ▸ | CDK2 | P24941 | 20/20 | 0.49 |
| ▸ | CCND1 | P24385 | 16/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 16/20 | 0.49 |
| ▸ | CDK4 | P11802 | 7/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.49 |
| ▸ | CDK9 | P50750 | 6/20 | 0.49 |
| ▸ | CCND3 | P30281 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24669568 | 0.82 | CCNE1 (0.51) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24669184 | 0.82 | CCNE1 (0.53) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24670061 | 0.82 | CCNE1 (0.53) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24669606 | 0.80 | CCNE1 (0.51) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24670053 | 0.79 | PTGS2 (0.34) | CCND1CDK4CCND3 | |
| SCHEMBL24668700 | 0.78 | CCNE1 (0.56) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24669062 | 0.77 | CCNE1 (0.59) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24668675 | 0.77 | CCNE1 (0.53) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24669126 | 0.77 | CCNE1 (0.55) | CCNE1CDK2CCND1CDK6CDK4 | |
| SCHEMBL24669143 | 0.76 | CCNE1 (0.53) | CCNE1CDK2CCND1CDK6CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |