Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 5/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | USP1 | O94782 | 1/20 | 0.34 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670411 | 0.86 | HTT (0.53) | HTTAGTR1AGTR2PPARGRXFP1 | |
| SCHEMBL24670075 | 0.83 | CA1 (0.39) | HTTPPARGRXFP1THRBUSP1 | |
| SCHEMBL4712339 | 0.77 | HTT (0.76) | HTTCCNE1CDK2POLBLMNA | |
| SCHEMBL24669161 | 0.74 | HTT (0.52) | HTTAGTR1AGTR2PPARGRXFP1 | |
| SCHEMBL14914628 | 0.72 | HTT (0.65) | HTTPPARGPOLBLMNA | |
| SCHEMBL24669149 | 0.71 | HTT (0.56) | HTTAGTR1AGTR2RXFP1THRB | |
| SCHEMBL24669124 | 0.71 | HTT (0.50) | HTTAGTR1AGTR2CCNE1CDK2 | |
| SCHEMBL24668698 | 0.71 | HTT (0.50) | HTTAGTR1AGTR2RXFP1THRB | |
| SCHEMBL1521623 | 0.70 | HTT (0.55) | HTTAGTR1AGTR2THRBPOLB | |
| SCHEMBL24670415 | 0.69 | CA1 (0.42) | HTTPPARGRXFP1THRBUSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |