Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | AKT2 | P31751 | 2/20 | 0.33 |
| ▸ | USP1 | O94782 | 1/20 | 0.32 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670415 | 0.86 | CA1 (0.42) | CA1CA2CA7CA13PPARG | |
| SCHEMBL24670077 | 0.83 | HTT (0.53) | PPARGHTTCCNE1CDK2CDK5 | |
| SCHEMBL2554057 | 0.78 | PPARG (0.51) | CA1CA2CA7CA13PPARG | |
| SCHEMBL4712462 | 0.77 | HTT (0.51) | CA1CA2CA7CA13HTT | |
| SCHEMBL24669163 | 0.74 | CA1 (0.39) | CA1CA2CA7CA13PPARG | |
| SCHEMBL14914225 | 0.72 | PPARG (0.53) | CA1CA2CA7CA13PPARG | |
| SCHEMBL24669160 | 0.72 | CA1 (0.52) | CA1CA2CA7CA13HTT | |
| SCHEMBL24670094 | 0.72 | CA1 (0.49) | CA1CA2CA7CA13PPARG | |
| SCHEMBL24668699 | 0.71 | CA2 (0.47) | CA1CA2CA7CA13HTT | |
| SCHEMBL24669128 | 0.71 | CA1 (0.52) | CA1CA2CA7CA13HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |