Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 8/20 | 0.41 |
| ▸ | IL2 | P60568 | 1/20 | 0.40 |
| ▸ | PIP5K1C | O60331 | 7/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | GPR183 | P32249 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.33 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.32 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.32 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30066501 | 1.00 | ITK (0.41) | ITKIL2PIP5K1CTNKSPARP1 | |
| Hydrochloric Acid SCHEMBL30066660 | 0.99 | ITK (0.41) | ITKIL2PIP5K1CTNKSPARP1 | |
| SCHEMBL24670156 | 0.90 | ITK (0.39) | ITKIL2PIP5K1CPARP1 | |
| SCHEMBL29990936 | 0.90 | ITK (0.44) | ITKIL2PIP5K1CGPR183 | |
| SCHEMBL24671834 | 0.90 | ITK (0.44) | ITKIL2PIP5K1CGPR183 | |
| SCHEMBL24671679 | 0.90 | ITK (0.44) | ITKIL2PIP5K1CGPR183 | |
| SCHEMBL24671438 | 0.88 | ITK (0.43) | ITKIL2PIP5K1CGPR183 | |
| SCHEMBL30066232 | 0.85 | ITK (0.42) | ITKIL2PIP5K1C | |
| SCHEMBL24669867 | 0.85 | ITK (0.42) | ITKIL2PIP5K1C | |
| SCHEMBL30066326 | 0.85 | ITK (0.42) | ITKIL2PIP5K1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |