Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 4/20 | 0.43 |
| ▸ | IL2 | P60568 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | PIP5K1C | O60331 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24671350 | 0.93 | KDR (0.46) | ITKIL2KDRHPGDTSHR | |
| SCHEMBL24671834 | 0.93 | ITK (0.44) | ITKIL2KDRRIPK1GPR183 | |
| SCHEMBL24671679 | 0.93 | ITK (0.44) | ITKIL2KDRRIPK1GPR183 | |
| SCHEMBL29990936 | 0.93 | ITK (0.44) | ITKIL2KDRRIPK1GPR183 | |
| SCHEMBL30066501 | 0.88 | ITK (0.41) | ITKIL2GPR183PIP5K1C | |
| SCHEMBL24670186 | 0.88 | ITK (0.41) | ITKIL2GPR183PIP5K1C | |
| SCHEMBL30066232 | 0.87 | ITK (0.42) | ITKIL2KDRHRH4PIP5K1C | |
| SCHEMBL30066326 | 0.87 | ITK (0.42) | ITKIL2KDRHRH4PIP5K1C | |
| SCHEMBL24669867 | 0.87 | ITK (0.42) | ITKIL2KDRHRH4PIP5K1C | |
| Hydrochloric Acid SCHEMBL30066660 | 0.87 | ITK (0.41) | ITKIL2GPR183PIP5K1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |