Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 9/20 | 0.66 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670465 | 0.91 | MAPKAPK2 (0.64) | MAPKAPK2IRAK4NAMPTPTPN1KLK7 | |
| Trifluoroacetic Acid SCHEMBL29803685 | 0.85 | MAPKAPK2 (0.56) | MAPKAPK2IRAK4NAMPTPTPN1MAPT | |
| SCHEMBL24892281 | 0.81 | MAPKAPK2 (0.56) | MAPKAPK2NAMPTPLAUSMYD3KLKB1 | |
| SCHEMBL29803255 | 0.81 | MAPKAPK2 (0.56) | MAPKAPK2NAMPTPLAUSMYD3KLKB1 | |
| SCHEMBL24669274 | 0.80 | MAPKAPK2 (0.59) | MAPKAPK2IRAK4PTPN1MAPT | |
| SCHEMBL24669649 | 0.80 | MAPKAPK2 (0.50) | MAPKAPK2NAMPTPLAUSMYD3KLKB1 | |
| SCHEMBL24671037 | 0.78 | MAPKAPK2 (0.46) | MAPKAPK2NAMPTPLAUSMYD3KLKB1 | |
| SCHEMBL24670348 | 0.77 | TP53 (0.46) | MAPKAPK2NAMPTPLAUPTPN1KLKB1 | |
| SCHEMBL24892041 | 0.76 | MAPKAPK2 (0.52) | MAPKAPK2NAMPTPLAUKLKB1PLG | |
| SCHEMBL30182510 | 0.76 | MAPKAPK2 (0.52) | MAPKAPK2NAMPTPLAUKLKB1PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022192162-A1 | NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE | FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) | 2022-09-15 | — | — | WO | disclosed |
| WO-2022192162-A1 | NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE | FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) | 2022-09-15 | — | — | WO | disclosed |