SCHEMBL24670989

SCHEMBL24670989

C=C(/C=C\C)C(=O)NC(C)C

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.41
ALDH1A1 P00352 3/20 0.39
GAA P10253 1/20 0.39
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
MMP1 P03956 1/20 0.32
MMP2 P08253 1/20 0.32
MMP9 P14780 1/20 0.32
MMP8 P22894 1/20 0.32
CA9 Q16790 1/20 0.32
TP53 P04637 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18568663 0.86 TSHR (0.38) TSHRALDH1A1GAA
SCHEMBL5134786 0.81 ALDH1A1 (0.57) TSHRALDH1A1GAACA12CA1
SCHEMBL24670727 0.78 TSHR (0.38) TSHRALDH1A1GAAL3MBTL1
SCHEMBL19197723 0.77 TSHR (0.34) TSHRALDH1A1GAACA12CA1
SCHEMBL23713438 0.77 TSHR (0.56) TSHRALDH1A1GAACA12CA1
SCHEMBL24670297 0.76
SCHEMBL28369798 0.75
SCHEMBL4104641 0.75
SCHEMBL24254347 0.73
SCHEMBL18377771 0.73 CA12 (0.35) CA12CA1CA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed