Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670228 | 0.89 | ANPEP (0.39) | ANPEPDPP4TDP1CRHBPCRHR2 | |
| SCHEMBL10925232 | 0.87 | ANPEP (0.43) | ANPEPDPP4TDP1CRHBPCRHR2 | |
| Hydrochloric Acid SCHEMBL10982278 | 0.85 | ANPEP (0.42) | ANPEPDPP4TDP1CRHBPCRHR2 | |
| SCHEMBL30805797 | 0.84 | ANPEP (0.44) | ANPEPDPP4TDP1KMT2ACASP1 | |
| SCHEMBL31259865 | 0.79 | DPP4 (0.51) | DPP4USP2KMT2AMEN1LMNA | |
| SCHEMBL5326245 | 0.79 | DPP4 (0.51) | DPP4USP2KMT2AMEN1LMNA | |
| SCHEMBL12420865 | 0.79 | DPP4 (0.47) | DPP4USP2KMT2AMEN1TYMS | |
| SCHEMBL1040431 | 0.77 | DPP4 (0.49) | ANPEPDPP4TDP1USP2KMT2A | |
| SCHEMBL22041008 | 0.77 | MAPT (0.43) | ANPEPDPP4TDP1USP2KMT2A | |
| SCHEMBL28646985 | 0.77 | KMT2A (0.43) | TDP1USP2KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |