SCHEMBL24671117

SCHEMBL24671117

C=C(/C=C\C)NC(=O)c1ccc(C2=CCNCC2)cc1C

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
QDPR P09417 3/20 0.42
HTR2C P28335 7/20 0.37
SIGMAR1 Q99720 2/20 0.37
CCNT1 O60563 2/20 0.37
CDK9 P50750 2/20 0.37
NAMPT P43490 1/20 0.36
FTO Q9C0B1 1/20 0.36
MAPKAPK2 P49137 1/20 0.36
WNT3A P56704 1/20 0.35
KHK P50053 1/20 0.34
TBK1 Q9UHD2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24669376 0.89 QDPR (0.40) QDPRHTR2CSIGMAR1CCNT1CDK9
SCHEMBL24670128 0.81 CCNT1 (0.50) QDPRHTR2CSIGMAR1CCNT1CDK9
SCHEMBL24670321 0.78 QDPR (0.47) QDPRHTR2CSIGMAR1CCNT1CDK9
SCHEMBL29803546 0.78 QDPR (0.47) QDPRHTR2CSIGMAR1CCNT1CDK9
SCHEMBL29803699 0.74 MAPKAPK2 (0.44) QDPRHTR2CCCNT1CDK9NAMPT
SCHEMBL29804007 0.73 MAPKAPK2 (0.46) QDPRHTR2CSIGMAR1CCNT1CDK9
SCHEMBL29803746 0.73 CCNT1 (0.42) QDPRHTR2CSIGMAR1CCNT1CDK9
SCHEMBL29803540 0.72 HTR2C (0.43) QDPRHTR2CCCNT1CDK9NAMPT
SCHEMBL29803664 0.72 SLC2A1 (0.47) NAMPTMAPKAPK2
Trifluoroacetic Acid SCHEMBL29803385 0.72 QDPR (0.41) QDPRHTR2CSIGMAR1CCNT1CDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed