Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.60 |
| ▸ | BTK | Q06187 | 3/20 | 0.57 |
| ▸ | AR | P10275 | 4/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31055547 | 1.00 | CRBN (0.60) | CRBNBTKARDDB1PLK4 | |
| SCHEMBL29681788 | 0.95 | CRBN (0.65) | CRBNBTKARDDB1HPGDS | |
| SCHEMBL24206867 | 0.95 | CRBN (0.65) | CRBNBTKARDDB1HPGDS | |
| SCHEMBL26928997 | 0.91 | CRBN (0.60) | CRBNBTKARDDB1PLK4 | |
| SCHEMBL30692979 | 0.91 | CRBN (0.60) | CRBNBTKARDDB1PLK4 | |
| SCHEMBL31579239 | 0.90 | CRBN (0.63) | CRBNBTKARDDB1PLK4 | |
| SCHEMBL24832995 | 0.88 | CRBN (0.71) | CRBNDDB1HPGDSALDH1A1CHRM2 | |
| SCHEMBL24352301 | 0.88 | CRBN (0.71) | CRBNDDB1HPGDSALDH1A1CHRM2 | |
| SCHEMBL30680834 | 0.88 | CRBN (0.71) | CRBNDDB1HPGDSALDH1A1CHRM2 | |
| SCHEMBL20046223 | 0.88 | CRBN (0.71) | CRBNDDB1HPGDSALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |